Read all of this information carefully before you start taking this medicine.
Uprima 3 mg sublingual tablets (apomorphine
Each tablet contains 3 mg of apomorphine hydrochloride, equivalent to 2.56
mg of apomorphine.
The other ingredients are: microcrystalline cellulose, hypromellose,
citric acid, magnesium stearate, ascorbic acid, disodium edetate, silicon
dioxide, red iron oxide (E172), acesulfame potassium, Orange mint flavour (WONF
WL-28499) and mannitol.
is and what it is used for
Uprima tablets are sub-lingual
tablets each containing 3 mg of apomorphine (as hydrochloride). The 3 mg
tablet is available in packs of 2 and 4 sublingual tablets.
Uprima 3 mg tablets are brick red in
colour and are triangle shaped embossed with 3 on one side and the Abbott
logo on the other side.
Uprima is a medicine known as a
dopaminergic agonist which helps men achieve an erection by stimulating the
region of the brain, called the hypothalamus, thereby helping to produce the
natural signals which start the erection process in the penis. Sexual
stimulation is necessary for Uprima
to work. Uprima is different to
morphine and has no morphine-like properties.
Uprima is a therapy for the
treatment of men with erectile dysfunction (sometimes called ED or
impotence). This is a condition in which a man cannot get, or keep, a hard
penis (erection) sufficient for satisfactory sexual performance.
Before you take Uprima
Do not take Uprima if:
- You have ever had an allergic reaction to
apomorphine or any of the ingredients in Uprima.
Possible signs of an allergic reaction include rash, itching, swollen
face or lips and shortness of breath. Tell your Doctor if you get any of
- You have severe unstable angina, recent
myocardial infarction, severe heart failure or hypotension, and other
medical conditions which could make sexual activity dangerous. Always
consult your Doctor about your medical history.
- Your partner is pregnant or breastfeeding
You should tell your
- You have a deformity or disease of the
penis as these may require special care when using medicines such as Uprima.
- You experience severe
dizziness/lightheadedness or feel faint after taking Uprima,
especially if you also have severe nausea or vomiting, sweating, become
pale or become unusually hot. In these cases you should not attempt to
stand up. If you experience these symptoms or feel faint for any reason
you should lie down and raise your legs. The feeling of faintness should
- You are taking nitrates (often used for
the relief of angina or chest pains) or any medicines for hypertension
(high blood pressure).
- You have liver or kidney problems. Your
suitability for Uprima and/or
the appropriate dose may need to be considered by your doctor.
- You have abnormally high or low blood
pressure or are prone to dizzy spells or fainting.
- You are taking any other treatment for
erectile dysfunction. Uprima
should not be used with any other treatment for erectile dysfunction.
should not be given to children under the age of 18. No dose adjustment is
required for the elderly.
Taking alcohol with Uprima can
increase any undesirable effects, in particular low blood pressure. In
addition, taking alcohol can make it more difficult to obtain an erection.
Not for use in women.
and using machines:
Because some patients can experience dizziness, lightheadedness and,
uncommonly fainting, it is recommended that you do not drive or operate
machinery for at least 2 hours after taking Uprima
or until any such symptoms are fully resolved.
Taking other medicines: Please inform your doctor
You are taking nitrates
(often used for the relief of angina or chest pains) or any medicines
for hypertension (high blood pressure).
You are taking drugs which
affect the dopamine system (often used to treat Parkinson's disease,
disturbances of the mind or to prevent vomiting).
You should also inform your
doctor or pharmacist if you are taking or have recently taken any other
medicines, even those not prescribed.
How to take Uprima
Your Doctor will decide the dose of Uprima
which is suitable for you. Do not take more tablets than your Doctor has
prescribed. All patients should begin with the 2 mg tablet. If your erection
is not sufficient for satisfactory sexual activity at this dose and you have
not experienced side effects, you may increase the dose to the 3 mg tablet
following consultation with your doctor. You should not take more than 3 mg
in any 8 hour period.
When taking Uprima:
Swallow a small amount of
water to help moisten your mouth
Place one tablet of Uprima
under your tongue. The tablet will not work if you swallow it.
Let the tablet dissolve
under your tongue - this usually takes about 10 minutes (if any tablet
residue is left after 20 minutes it may be swallowed).
Sexual activity may begin as
soon as the Uprima is placed
under your tongue and you may proceed with intercourse when you and your
partner are ready.
Typically erections may be
achieved in under 20 minutes, although this varies from person to
You should not take more than 3
mg Uprima in any 8 hour period.
If Uprima does not help you get a
satisfactory erection tell your Doctor as your dose may need adjustment.
You should only take Uprima as
directed. If you take too many tablets or the wrong dose, contact your
Like all medicines, Uprima can have
side effects. These are generally mild and transient in nature.
Common undesirable effects are nausea, headache, dizziness, yawning,
sleepiness, infection, sore throat, pain, increased cough, rhinitis,
flushing, taste disorder and sweating.
Uncommonly, fainting has occurred. If you feel faint, follow the
instructions given under 'Do not take Uprima:'
If you have chest pains during intercourse, you should stop immediately and
contact your doctor.
If you have any undesirable effect which is severe or prolonged you should
tell your Doctor. If you notice any side effects not mentioned in this
leaflet, please inform your doctor or pharmacist.
Keep out of the reach and sight of children
Store your Uprima in the original package. Do not use this medicine after
the expiry date shown on the pack, or if the pack has been damaged or
to order Uprima.
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